David Lewis defends the following "non-circular definition of personhood": "something is a continuant person if and only if it is a maximal R-interrelated aggregate of person-stages. That is: if and only if it is an aggregate of person-stages, each of which is R-related to all the rest (and to itself), and it is a proper part of no other such aggregate." I give a counterexample, involving a person who is a part of another, much larger person, with a separate mental (...) life. I then offer an easy repair, which preserves the virtues of Lewis's definition without introducing any new vices. (shrink)

Engaging with the philosophical writings of Iris Murdoch, we submit that there are difficulties associated with providing a good description of morality that are intimately connected with difficulties in understanding other human beings. We suggest three senses in which moral philosophical reflection needs to account for our understanding of others: (1) the failure to understand someone is not merely an intellectual failure, but also engages us morally; (2) the moral question of understanding is not limited to the extent to which (...) we understand a particular person, but also presents itself in how we picture difficulties in understanding people; and (3) “philosophical pictures of morality” fundamentally shape the conceptual framework we use to investigate morality, as well as the analysis of morality we find illuminative and satisfactory. Exploring the implications of these claims, we ask what it means to think of others as the same, or as different, from ourselves. We then consider the ethical significance of finding, or not finding, our feet in our encounters with others, dwelling on how the metaphor of movement reveals one way in which we are never at peace in the exploration of morality. (shrink)

One of the standard examples in contemporary moral psychology originates in the works of social psychologist Jonathan Haidt. He treats people's responses to the story of Julie and Mark, two siblings who decide to have casual, consensual, protected sex, as facts of human morality, providing evidence for his social intuitionist approach to moral judgements. We argue that Haidt's description of the facts of the story and the reactions of the respondents as ‘morally dumbfounded’ presupposes a view about moral reasoning that (...) is more substantial than he acknowledges. Drawing on the philosophical work by Iris Murdoch and Cora Diamond, we explore how different descriptions of human morality, sexuality, and family relations engage us in evaluations about distinctive features of human life and language that go deeper than Haidt envisages. Thus, we show the need to attend to the concepts used to describe the facts of human moral psychology and the pictures of morality these concepts reveal about the researcher's own understanding of moral experience. This points to the particular responsibility any researcher into human moral psychology has for ensuring that the descriptions they offer are attuned to the complexities of the lives of those they form theories about and that these do not appear conceptually confounding. (shrink)

Are there reasons for loving? How can I promise to love someone? Is there such a thing as unconditional love? Am I responsible for loving or for failing to love someone? Can there be love without idealization? -/- This work sets out to show that many of the questions we raise when philosophizing about love are expressive of confusions about what we talk about when we talk about love. Addressing questions pertaining to philosophical discussions about emotions, personal identity and the (...) meaning of language and morality, the author shows how these confusions can be dissolved by carefully attending to our different conversations about love. Her investigations show that many of the challenges we face when reflecting on love do not have the kind of scientific or strictly philosophical character that would allow us to settle them once and for all. They are moral in character and gain their significance from the questions they raise about the place love has in our own lives. The kind of reflection on the meaning of love suggested in this work does not depend on any new discoveries about the phenomena of love. It is available to anyone who is prepared to reflect on our ways of speaking and to question our preconceptions of love and of philosophy. Through such reflection our understanding of love may continually deepen. (shrink)

The social intuitionist approach to moral judgments advanced by social psychologist Jonathan Haidt presupposes that it is possible to provide an explanation of the human moral sense without normative implications. By contrast, Iris Murdoch’s philosophical work on moral psychology suggests that every description of morality necessarily involves evaluative features that reveal the thinker’s own moral attitudes and implicit philosophical pictures. In the light of this, we contend that Haidt’s treatment of the story about Julie and Mark, two siblings who decide (...) to have casual, protected, and in his view harmless sex, provides a too simplistic picture of what is involved in understanding human morality. Despite his aim to explain the roots of moral judgments, he fails to provide a deeper understanding of morality in two different respects. First, he does so by suggesting that his story contains all the relevant information needed to take a moral stand on it, and by rejecting as irrelevant the wider human context in which questions about sexual and family relations arise. Second, he simplifies the responses of the people who are subject to his experiment by disregarding their various reasons for disapproving and by equating understanding human morality with explaining an impersonal psychological process. (shrink)

Speaks defends the view that propositions are properties: for example, the proposition that grass is green is the property being such that grass is green. We argue that there is no reason to prefer Speaks's theory to analogous but competing theories that identify propositions with, say, 2-adic relations. This style of argument has recently been deployed by many, including Moore and King, against the view that propositions are n-tuples, and by Caplan and Tillman against King's view that propositions are facts (...) of a special sort. We offer our argument as an objection to the view that propositions are unsaturated relations. (shrink)

I am grateful to Catharine Abell and Gregory Currie for their incisive and productive commentaries on Apt Imaginings. In what follows, I will try to respond to.

Relativity theory is often said to support something called ‘the four-dimensional view of reality’. But there are at least three different views that sometimes go by this name. One is ‘spacetime unitism’, according to which there is a spacetime manifold, and if there are such things as points of space or instants of time, these are just spacetime regions of different sorts: thus space and time are not separate manifolds. A second is the B-theory of time, according to which the (...) past, present, and future are all equally real and there is nothing metaphysically special about the present. A third is perdurantism, according to which persisting material objects are made up of different temporal parts located at different times. We sketch routes from relativity to unitism and to the B-theory. We then discuss some routes to perdurantism, via the B-theory and via unitism. (shrink)

Do Russellian propositions have their constituents as parts? One reason for thinking not is that if they did, they would generate apparent counterexamples to plausible mereological principles. As Frege noted, they would be in tension with the transitivity of parthood. A certain small rock is a part of Etna but not of the proposition that Etna is higher than Vesuvius. So, if Etna were a part of the given proposition, parthood would fail to be transitive. As William Bynoe has noted (...) (speaking of facts rather than propositions), they would seem to violate certain supplementation principles. Consider the singular proposition, concerning identity, that it is identical with itself. Given the relevant form of Russellianism, this proposition would have identity as a proper part, but it would not have any parts disjoint from identity, and indeed it would not have even a single pair of disjoint parts, in violation of various supplementation principles. This chapter offers a unified solution to the problems about transitivity and supplementation. One key ingredient in the solution is the view that parthood is a four-place relation expressed by ‘x at y is a part of z at w’. Another key ingredient is the view that the semantic contents of predicates and sentential connectives have ‘slots’ or ‘argument positions’ in them. (Both ingredients are independently motivated elsewhere.) Four-place analogues of the transitivity and supplementation principles are set out, and it is argued that these are not threatened by the examples from Frege and Bynoe. (shrink)

Slot theory is the view that (i) there exist such entities as argument places, or ‘slots’, in universals, and that (ii) a universal u is n-adic if and only if there are n slots in u. I argue that those who take properties and relations to be abundant, fine-grained, non-set-theoretical entities face pressure to be slot theorists. I note that slots permit a natural account of the notion of adicy. I then consider a series of ‘slot-free’ accounts of that notion (...) and argue that each of them has significant drawbacks. (shrink)

Endurantism, the view that material objects are wholly present at each moment of their careers, is under threat from supersubstantivalism, the view that material objects are identical to spacetime regions. I discuss three compromise positions. They are alike in that they all take material objects to be composed of spacetime points or regions without being identical to any such point or region. They differ in whether they permit multilocation and in whether they generate cases of mereologically coincident entities.

I formulate an account, in terms of essence and ground, that explains why atomic Russellian propositions have the truth conditions they do. The key ideas are that (i) atomic propositions are just 0-adic relations, (ii) truth is just the 1-adic version of the instantiation (or, as I will say, holding) relation (Menzel 1993: 86, note 27), and (iii) atomic propositions have the truth conditions they do for basically the same reasons that partially plugged relations, like being an x and a (...) y such that Philip gave x to y, have the holding conditions they do. The account is meant to be mainly of intrinsic interest, but I hope that it goes some distance toward answering an objection to classical theories of propositions put forward by King (2014), who writes that ‘since the classical conception of propositions as things that have truth conditions by their very natures and independently of minds and languages is incapable of explaining how or why propositions have truth conditions, it is unacceptable’ (2014: 47). Propositions do have their truth conditions ‘by their very natures’ and ‘independently of minds and languages’. But a fact about a given entity can hold by the very nature of that entity without being a fundamental fact. I argue that this is plausibly the case for atomic Russellian propositions and the facts about their truth conditions. A fact about the truth conditions of such a proposition holds by the very nature of the given proposition but is metaphysically grounded in facts about that proposition’s parts and their essences. If my account is correct, then the supposedly intractable problem of explaining why the given propositions have the truth conditions they do reduces to the problem of explaining why relations have the holding essences they do, which few seem to have found worrisome . (shrink)

Ned Markosian has recently defended a new theory of composition, which he calls regionalism : some material objects xx compose something if and only if there is a material object located at the fusion of the locations of xx. Markosian argues that regionalism follows from what he calls the subregion theory of parthood. Korman and Carmichael agree. We provide countermodels to show that regionalism does not follow from, even together with fourteen potentially implicit background principles. We then show that regionalism (...) does follow from five of those background principles together with and two additional principles connecting parthood and location, which we call and. While the additional principles are not uncontroversial, our conjecture is that many will find them attractive. We conclude by mentioning that fills a previously unnoticed gap in the formal theory of location presented in Parsons. (shrink)

Personal time, as opposed to external time, has a certain role to play in the correct account of death and immortality. But saying exactly what that role is, and what role remains for external time, is not straightforward. I formulate and defend accounts of death and immortality that specify these roles precisely.

I argue for the recognition of a particular kind of interest that one has in freedom of expression: an interest served by expressive activity in forming and discovering one’s own beliefs, desires, and commitments. In articulating that interest, I aim to contribute to a family of theories of freedom of expression that find its justification in the interests that speakers have in their own speech or thought, to be distinguished from whatever interests they may also have as audiences or third (...) parties for speech. Although there are many differences among such speaker-centered theories, a core commitment that most share is that expressive liberty plays a fundamental role in securing or constituting some form of individual self-realization. My account is a defense and elaboration of what I take to be one specific way in which the nature of such self-realization should be understood. In my proposal, self-realization is sometimes internally related to the very activity of expression, viz, expressing ourselves is one way in which we come to form and know our own minds. (shrink)

I defend coincidentalism (the view that some pluralities have more than one mereological fusion) and restricted composition (the view that some pluralities lack mereological fusions) against recent arguments due to Theodore Sider.

In The Life of a Style, Jonathan Gilmore claims that such narrative developments inhere in the history of art itself.By exploring such topics as the discovery ...

Teachers in vocational education face two problems. (1) Learning involves the ability to transcend and modify learned knowledge to new circumstances. How should vocational education prepare students for future, unknown tasks? (2) Students should strive to produce work of good quality. How does vocational education help them develop their faculty of judgment to differentiate between better and worse quality? These two ques- tions are tightly interwoven. The paper compares the didactics of philosophy and sloyd. Both developed independently, but their solutions (...) to how one advances the capacity for reflective judgment are similar. Central to this capacity is not merely devising efficient means to work towards pre-existing aims, but to reflect in practice on what one’s aim are and should be. This implies reflection on what future problems, as well as solutions to them, demand of us cognitively, socially and morally. (shrink)

In the title essay of The Philosophical Disenfranchisement of Art Arthur Danto describes two dominant strains of the philosophy of art in its Platonic beginnings: one that art is dangerous, and thus subject to political censorship or control, and the other that art exists at several removes from the ordinary reality, impotent to effect any meaningful change in the human world.1 These two ways of understanding art, really two charges laid at art’s door, seem contradictory, he writes, until one realizes (...) that the second is a philosophical response to the first. In a ‘‘kind of warfare between philosophy and art’’ philosophy sees art as a rival, as a challenger to the supremacy of reason over the minds of men. Thus Danto describes the premise advanced in Book X of the Republic that art is mimesis, or that of The Ion that the artist lacks knowledge of what he does, as components of a powerfully disabling theory of art, designed not so much to come to terms with the essence of art as to neutralize its power through metaphysical exile, denying art causal efficacy or epistemic validity in the real world. And the history of aesthetics, in Danto’s view, continues this disenfranchisement, whether in the Kantian ephemeralization of art as an object of disinterested judgment, outside the realm of human practical and political concerns, or in the Hegelian ‘‘takeover’’ of art, in which it is demoted as an inadequate form of philosophy. (shrink)

This chapter addresses the application of contemporary theories of the imagination—largely drawn from cognitive psychology—to our understanding of film. Topics include the role of the imagination in our learning what facts hold within a fictional film, including what characters’ motivations, beliefs, and feelings are; how our perceptual experience of a film explains our imaginative visualizing of its contents; how fictional scenarios in films generate certain affective and evaluative responses; and how such responses compare to those we have toward analogous circumstances (...) in real life. (shrink)

Delivery riders became frontline workers who assisted everyone in getting their daily supplies. They transported them to their destinations when the pandemic started, and everyone had to stay home to stop the COVID-19 virus from spreading. Thus, this study explores the experiences, challenges, and coping mechanisms of 15 Female Delivery Riders in Bulacan, Philippines. The study employed Heideggerian Phenomenology and Interpretative Phenomenological Analysis (IPA). Further, the following themes arise: (1) The Realist, (2) The Accommodated, (3) The Vulnerable, and (4) The (...) Determined. These themes highlighted the experiences and challenges faced by the participants. Moreover, it is highly suggested that female employees should be given preferential assistance given their physical capabilities and role in the family. Thus, local government units should provide an alternative source of income that will allow them to have quality time with their family, especially their children. (shrink)

This article explores the enduring mysteries of consciousness and the afterlife, two enigmatic topics that have fascinated humanity for ages. Despite extensive scientific efforts, the existence of an afterlife remains unproven, and understanding consciousness remains a significant challenge. The research introduces innovative hypotheses through simple thought experiments with empirical evidence and robust theoretical foundations. It delves into the complexities of consciousness, its relationship with the brain, and the need for interdisciplinary approaches encompassing physics, psychology, and philosophy. Boldly contemplating the probability (...) of a continuous consciousness after death, the study argues that existing evidence strongly supports this idea. Beyond theoretical implications, it envisions practical outcomes, suggesting that insights into these mysteries could enhance human well-being and contribute to a more harmonious world. In summary, this article embarks on a quest to shed light on age-old questions about consciousness and the afterlife. Through fresh methodologies, it aims to provide new perspectives that could reshape our understanding of existence and inspire intellectuals to positive individual and societal advancements. -/- . (shrink)

Each of these books offers a richly developed and nuanced account of the nature of fiction. And each poses major challenges to a view about which there is a near-consensus. Catharine Abell draws on a theory of the institutions of fiction to advance a systematic re-envisioning of the metaphysics and epistemology of the contents of stories. Gregory Currie argues that fiction’s relationship to the imagination, and the way stories communicate their contents to readers, seriously undermine fiction’s cognitive values.

The so-called Final Ranking of the Philebus offers Socrates’ final evaluation of the relative merits of pleasure and reason in the best life. I begin by examining two common lines of interpretation as they address the criterion according to which the final ranking is organized. I then discuss the role ‘similarity’ has in organizing the investigation throughout the dialogue, from the initial comparison of the two lives (of reason and pleasure singly) down through the final ranking. I then consider the (...) thematic discussions of pleasure and reason separately, arguing that their treatments display an intriguing structural similarity. Next, I propose my own reading of the final ranking, whereby the ‘dependence’ relation at work in those two specific discussions may be see as the through-line of all (now five) tiers of the final ranking. I conclude by suggesting that this interpretation is able to preserve what is worthwhile in the two traditional lines of interpretation, while avoiding the pitfalls that tend to accompany them. (shrink)

A defense of the view that (i) to be alive is to be actively undergoing (not merely capable of undergoing) certain vital processes, that (ii) to die is cease to be capable of undergoing those processes (not to cease undergoing them), and that (iii) organisms in cryptobiosis (suspended animation) are not undergoing those processes but are capable of doing so, and are neither alive nor dead.

A primary dimension of our engagement with fictional works of art – paradigmatically literary, dramatic, and cinematic narratives – is figuring out what is true in such representations, what the facts are in the fictional world. These facts include not only those that ground any genuine understanding of a story – say, that it was his own father whom Oedipus killed – but also those that may be missed in even a largely competent reading, say, that Emma Bovary's desires and (...) dissatisfactions are fed by reading romance novels. (shrink)

I introduce a puzzle about contact and de re temporal predication in relativistic spacetime. In particular, I describe an apparent counterexample to the following principle, roughly stated: if B is never in a position to say ‘I was touching A, I am touching A, and I will be touching A’, then (time travel aside) A is never in a position to say ‘I was touching B, I am touching B, and I will be touching B’. In the case I present, (...) the most that A is ever in a position to say is: ‘I am now touching B, but this is the only instant at which this will ever be so’. B, on the other hand, can say: ‘I was formerly touching A, I am currently touching A, and I will in the future be touching A’. (And neither object is a time traveler.). (shrink)

According to what Barry Dainton calls the 'Strong Introspectibility thesis', it is a necessary truth that mental states S and S* are co-conscious (experienced together) if and only if they are 'jointly introspectible', i.e., if and only if it is possible for there to be some single state of introspective awareness that represents both S and S*. Dainton offers two arguments for the conclusion that joint introspectibility is unnecessary for co-consciousness. In these comments I attempt to show, first, that Dainton's (...) arguments fail, and, second, that joint introspectibility is actually insufficient for co-consciousness. (As to whether it is also unnecessary, I take no stance.). (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system correctly diagnoses (...) Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)

In this article, we develop a new approach to integrating philosophical phenomenology with qualitative research. The approach uses phenomenology’s concepts, namely existentials, rather than methods such as the epoché or reductions. We here introduce the approach to both philosophers and qualitative researchers, as we believe that these studies are best conducted through interdisciplinary collaboration. In section 1, we review the debate over phenomenology’s role in qualitative research and argue that qualitative theorists have not taken full advantage of what philosophical phenomenology (...) has to offer, thus motivating the need for new approaches. In section 2, we introduce our alternative approach, which we call Phenomenologically Grounded Qualitative Research (PGQR). Drawing parallels with phenomenology’s applications in the cognitive sciences, we explain how phenomenological grounding can be used to conceptually front-load a qualitative study, establishing an explicit focus on one or more structures of human existence, or of our being in the world. In section 3, we illustrate this approach with an example of a qualitative study carried out by one of the authors: a study of the existential impact of early parental bereavement. In section 4, we clarify the kind of knowledge that phenomenologically grounded studies generate and how it may be integrated with existing approaches. (shrink)

We provide an analysis of the public's having warranted epistemic trust in science, that is, the conditions under which the public may be said to have well-placed trust in the scientists as providers of information. We distinguish between basic and enhanced epistemic trust in science and provide necessary conditions for both. We then present the controversy regarding the connection between autism and measles–mumps–rubella vaccination as a case study to illustrate our analysis. The realization of warranted epistemic public trust in science (...) requires various societal conditions, which we briefly introduce in the concluding section. (shrink)

Here, I discuss how natural biological evolution might have selected human origin and the psychology of the better mind-brain. However, all humans are closely related; why do we make crimes, war, hate, and jealousy their primary reasons and overcoming methodologies? How can they gain their best happiness? What kind of philosophy apply to annalize this big question and convince humankind to evolve their mind? How we could achieve our optimum potential happiness by developing hidden intelligence to make the world a (...) happier place to live in. (shrink)

How does consciousness vary across the animal kingdom? Are some animals ‘more conscious’ than others? This article presents a multidimensional framework for understanding interspecies variation in states of consciousness. The framework distinguishes five key dimensions of variation: perceptual richness, evaluative richness, integration at a time, integration across time, and self-consciousness. For each dimension, existing experiments that bear on it are reviewed and future experiments are suggested. By assessing a given species against each dimension, we can construct a consciousness profile for (...) that species. On this framework, there is no single scale along which species can be ranked as more or less conscious. Rather, each species has its own distinctive consciousness profile. (shrink)

A review of Personhood, Ethics, and Animal Cognition: Situating Animals in Hare’s Two-Level Utilitarianism, by Gary E. Varner. New York, NY: Oxford University Press, 2012. Pp. xv + 336. H/b £40.23. and The Philosophy of Animal Minds, edited by Robert W. Lurz. New York, NY: Cambridge University Press, 2009. Pp. 320. P/b £20.21.

I examine the epistemic import of collaborative research in science. I develop and defend a functional explanation for its growing importance. Collaborative research is becoming more popular in the natural sciences, and to a lesser degree in the social sciences, because contemporary research in these fields frequently requires access to abundant resources, for which there is great competition. Scientists involved in collaborative research have been very successful in accessing these resources, which has in turn enabled them to realize the epistemic (...) goals of science more effectively than other scientists, thus creating a research environment in which collaboration is now the norm. (shrink)

The dominant framework for addressing procreative ethics has revolved around the notion of harm, largely due to Derek Parfit’s famous non-identity problem. Focusing exclusively on the question of harm treats what procreators owe their offspring as akin to what they would owe strangers (if they owe them anything at all). Procreators, however, usually expect (and are expected) to parent the persons they create, so we cannot understand what procreators owe their offspring without also appealing to their role as prospective parents. (...) I argue that prospective parents can wrong their future children just by failing to act well in their role as parents, whether or not their offspring are ultimately harmed or benefitted by their creation. Their obligations as prospective parents bear on the motivations behind their reproductive choices, including the choice to select for some genetic trait in their offspring. Even when procreators’ motivations aren’t malicious, or purely selfish, they can still fail to recognize and act for the end of the parental role. Procreators can wrong their offspring by selecting for some genetic trait, then, when doing so would violate their obligations as prospective parents, or when their motivation for doing so is antithetical to the end of the parental role. (shrink)

Many accounts of the morality of abortion assume that early fetuses must all have or lack moral status in virtue of developmental features that they share. Our actual attitudes toward early fetuses don’t reflect this all-or-nothing assumption: early fetuses can elicit feelings of joy, love, indifference, or distress. If we start with the assumption that our attitudes toward fetuses reflect a real difference in their moral status, then we need an account of fetal moral status that can explain that difference. (...) I argue that we can have or lack relational obligations to early fetuses in light of our own activities or choices, independent of the fetus’s own features or properties. Those relational obligations make the early fetus morally considerable to the persons who stand in a moral relation to it. Pregnant persons (and other participants in the procreative process) can come to have relational obligations to an early fetus just in virtue of their own decision to create a person, either by intentionally getting pregnant or by deciding to continue a pregnancy. That decision not only makes it appropriate for them to care about the fetus, but it also generates obligations to the fetus that they didn’t have before that decision. (shrink)

The idea that there could be spatially extended mereological simples has recently been defended by a number of metaphysicians (Markosian 1998, 2004; Simons 2004; Parsons (2000) also takes the idea seriously). Peter Simons (2004) goes further, arguing not only that spatially extended mereological simples (henceforth just extended simples) are possible, but that it is more plausible that our world is composed of such simples, than that it is composed of either point-sized simples, or of atomless gunk. The difficulty for these (...) views lies in explaining why it is that the various sub-volumes of space occupied by such simples, are not occupied by proper parts of those simples. Intuitively at least, many of us find compelling the idea that spatially extended objects have proper parts at every sub-volume of the region they occupy. It seems that the defender of extended simples must reject a seemingly plausible claim, what Simons calls the geometric correspondence principle (GCP): that any (spatially) extended object has parts that correspond to the parts of the region that it occupies (Simons 2004: 371). We disagree. We think that GCP is a plausible principle. We also think it is plausible that our world is composed of extended simples. We reconcile these two notions by two means. On the one hand we pay closer attention to the physics of our world. On the other hand, we consider what happens when our concept of something—in this case space—contains elements not all of which are realized in anything, but instead key components are realized in different features of the world. (shrink)

Objective: Lung cancer is the most common cause of morbidity and mortality. Platinum-based chemotherapy, which is the primary line of treatment, offers limited benefit due to drug resistance and side effects. Berberine (BBR), which is characterised by its potent and safe anticancer activity, represents a promising combination option in chemotherapy. To overcome the limitations in lung cancer chemotherapy, we investigated whether BBR and cisplatin (CIS) exert synergistic effects on non-small cell lung cancer cell line (A549) based on cytotoxicity and apoptotic (...) response markers. -/- Methods: The potential cytotoxic effects of the combination treatment were evaluated using the MTT and Chou-Talalay methods. Elisa assays were also performed to measure the levels of the pro-apoptotic protein Bax and the effector protein caspase (Cas)-3. -/- Results: The results showed that BBR alone reduced A549 cell viability in a dose-dependent manner and synergized with CIS (CI =0.34±0.05 at IC50 concentrations). Elisa results showed that the combined treatment (both at IC50 concentrations) modulated apoptotic signalling pathways in A549 cells. Bax and Cas3 protein levels were dramatically enhanced in A549 cells treated with CIS +BBR compared to control (0.5% DMSO) (p < 0.001). -/- Conclusion: Our results suggest that BBR can synergistically enhance the therapeutic effect of CIS in A549 cells. The potential therapeutic efficacy of BBR as part of a combination in current chemotherapy should be supported by in-depth research and clinical studies on the molecular mechanisms associated with cancer. (shrink)

The Aristotelian view that the moral virtues–the virtues of character informed by practical wisdom–are essential to an individual's happiness, and are thus in an individual's self-interest, has been little discussed outside of purely scholarly contexts. With a few exceptions, contemporary philosophers have tended to be suspicious of Aristotle's claims about human nature and the nature of rationality and happiness. But recent scholarship has offered an interpretation of the basic elements of Aristotle's views of human nature and happiness, and of reason (...) and virtue, that brings them more into line with common-sense thinking and with contemporary philosophical and empirical psychology. This makes it fruitful to reexamine the question of the role of virtue in self-interest. (shrink)

David Hull accounts for the success of science in terms of an invisible hand mechanism, arguing that it is difficult to reconcile scientists' self-interestedness or their desire for recognition with traditional philosophical explanations for the success of science. I argue that we have less reason to invoke an invisible hand mechanism to explain the success of science than Hull implies, and that many of the practices and institutions constitutive of science are intentionally designed by scientists with an eye to realizing (...) the very goals that Hull believes need to be explained by reference to an invisible hand mechanism. Thus, I reduce the scope of Hull's invisible hand explanation and supplement it by appealing to a hidden hand explanation. (shrink)